Diagnostic Neuropathology

Mini-review: Eosinophils, a Useful Diagnostic Clue in Surgical Neuropathology

Eosinophils are one of the polymorphonuclear granulocytes derived from bone marrow stem cells, and they contain many small cytoplasmic granules that stain bright red with eosin or brick-red with Romanowsky staining. Eosinophilic infiltration is also present in various human central nervous system (CNS) diseases such as parasitic infection, transverse myelitis, vasculitis, Langerhans cell histio...

Practical Surgical Neuropathology: Foundational Principles and Diagnostic Challenges

Parkinsonism--neuropathology.

for willed movements only, but subsequently also for following movements and the upward movement of the eyeballs which occurs on closing the lids. At a later stage, lateral conjugate gaze is also affected, the loss again first involving voluntary movements and at a later stage reflexly induced or following movements. Tremor is not a feature of this condition, which is unlikely to be missed if o...

The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology

Small fibre neuropathy (SFN), a condition dominated by neuropathic pain, is frequently encountered in clinical practise either as prevalent manifestation of more diffuse neuropathy or distinct nosologic entity. Aetiology of SFN includes pre-diabetes status and immune-mediated diseases, though it remains frequently unknown. Due to their physiologic characteristics, small nerve fibres cannot be i...

[Neuropathology of frontotemporal dementia].

Frontotemporal dementia (FTD) is a clinical phenotype of dementia, characterized by complex of clinical symptoms, including disinhibition, character change, increased appetite, sexual misconduct and language problems. Frontotemporal lobar degeneration (FTLD) is a pathological classification of neurodegenerative disorder and its core consists of Pick's disease (PiD). Historically, PiD was morpho...